2414254-49-0
2414254-49-0
Chemical Structure
Gly-Cyclopropane-Exatecan
- CAS No.: 2414254-49-0
- Formula:C32H34FN5O7
- Molecular Weight:619.64
InChIKey: CEFSJFYTDCGHFB-XXCFHSPASA-N
SMILES: NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O
Biological Activity: Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].
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Gly-Cyclopropane-Exatecan | Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro. | |||||||||||||||||||||
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