2414508-40-8
Chemical Structure
Hypoxystat
- CAS No.: 2414508-40-8
- Formula:C21H21NO5
- Molecular Weight:367.40
InChIKey: ZHAQYOLOVKUFPI-INIZCTEOSA-N
SMILES: O=C(N1CCCC[C@H]1COC2=CC=CC(O)=C2C=O)C3=C(C=O)C=CC=C3
Biological Activity: Hypoxystat is an orally active hypoxia mimetic. HypoxyStat increases Hemoglobin’s oxygen affinity, limiting oxygen offloading to the tissues and inducing local tissue hypoxia. Hypoxystat reduces Iba1+ cells. HypoxyStat causes systemic hypoxia. Hypoxystat effectively rescues hyperglycemia in mouse models of type 1 and type 2 diabetes. HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome[1][2].
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Hypoxystat | 99.28% | Hypoxystat is an orally active hypoxia mimetic. HypoxyStat increases Hemoglobin’s oxygen affinity, limiting oxygen offloading to the tissues and inducing local tissue hypoxia. Hypoxystat reduces Iba1+ cells. HypoxyStat causes systemic hypoxia. Hypoxystat effectively rescues hyperglycemia in mouse models of type 1 and type 2 diabetes. HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome. | ||||||||||||||||||||
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References
- [1]. Martí-Mateos Y, et al. Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude. Cell Metab. 2026 Feb 19:S1550-4131(26)00018-5. [Content Brief]
- [2]. Blume SY, et al. HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity. Cell. 2025;188(6):1580-1588.e11. [Content Brief]
