2414633-49-9
2414633-49-9
Chemical Structure
CDK1/2/4-IN-1
- CAS No.: 2414633-49-9
- Formula:C15H16N2O2S
- Molecular Weight:288.36
IUPAC Name: (E)-3-(4-methoxyphenyl)-1-(5-methyl-2-(methylamino)thiazol-4-yl)prop-2-en-1-one
InChIKey: UFLGJZHPDAVXQK-RMKNXTFCSA-N
SMILES: O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
Biological Activity: CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
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CDK1/2/4-IN-1 | CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research. | |||||||||||||||||||||
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