2415225-30-6
Chemical Structure
Acid Ceramidase-IN-1
- CAS No.: 2415225-30-6
- Formula:C18H25N3O3
- Molecular Weight:331.41
IUPAC Name: N-isobutyl-6-(1-methylpiperidin-4-yl)-2-oxobenzo[d]oxazole-3(2H)-carboxamide
InChIKey: AYXQGWOLRJUITD-UHFFFAOYSA-N
SMILES: O=C(N1C(OC2=CC(C3CCN(C)CC3)=CC=C12)=O)NCC(C)C
Biological Activity: Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Acid Ceramidase-IN-1 | 99.81% | Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD). | ||||||||||||||||||||
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