2416049-12-0
Chemical Structure
LXRβ agonist-3
- CAS No.: 2416049-12-0
- Formula:C30H33N3O6S
- Molecular Weight:563.66
IUPAC Name: tert-butyl (3S)-2'-(3-((4-(hydroxymethyl)-3-(methylsulfonyl)phenyl)amino)phenyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
InChIKey: YIKYKYFYFWNCSE-WSXWNZDHSA-N
SMILES: O=C1[C@]2(C3=CC=CC=C3N1)[C@@H](C4=CC(NC5=CC(S(C)(=O)=O)=C(C=C5)CO)=CC=C4)N(CC2)C(OC(C)(C)C)=O
Biological Activity: LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].
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LXRβ agonist-3 | LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma. | |||||||||||||||||||||
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