2416095-06-0
2416095-06-0
Chemical Structure
CBR-470-1
- CAS No.: 2416095-06-0
- Formula:C14H20ClNO4S2
- Molecular Weight:365.89
IUPAC Name: (3R,4S)-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide
InChIKey: NFEQFEDSWINARK-KBPBESRZSA-N
SMILES: CC(C)CN[C@H]([C@@H](S(=O)(C1=CC=C(Cl)C=C1)=O)C2)CS2(=O)=O
Biological Activity: CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CBR-470-1 | 98.02% | CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade. | ||||||||||||||||||||
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References
- [1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604. [Content Brief]
- [2]. Zheng J, et, al. PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+. Aging (Albany NY). 2020 Jul 10;12(13):13388-13399. [Content Brief]
