2416146-10-4
2416146-10-4
Chemical Structure
NAcM-OPT hydrochloride
- CAS No.: 2416146-10-4
- Formula:C23H30Cl3N3O
- Molecular Weight:470.86
IUPAC Name: 1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea hydrochloride
InChIKey: DDYSTAUKIBWFNE-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3.Cl
Biological Activity:
NAcM-OPT (hydrochloride) is a protein interaction inhibitor. NAcM-OPT (hydrochloride) can disrupt the interaction between DCN1 and UBC12, with an IC50 value of 80 nM. NAcM-OPT (hydrochloride) can protect keratinocytes from H2O2-induced cell damage by promoting autophagy[1][2].
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NAcM-OPT hydrochloride | NAcM-OPT (hydrochloride) is a protein interaction inhibitor. NAcM-OPT (hydrochloride) can disrupt the interaction between DCN1 and UBC12, with an IC50 value of 80 nM. NAcM-OPT (hydrochloride) can protect keratinocytes from H2O2-induced cell damage by promoting autophagy. |
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References
- [1]. Fang Y, et al. Targeting the DCN1-UBC12 protein-protein interaction: novel approaches and future directions. Future Med Chem. 2019 Nov;11(22):2869-2871. [Content Brief]
- [2]. Xiong R, et al. NAcM-OPT protects keratinocytes from H2O2-induced cell damage by promoting autophagy. Ann N Y Acad Sci. 2024 Jul;1537(1):155-167. [Content Brief]
