2417651-42-2
Chemical Structure
Antitumor agent-69
- CAS No.: 2417651-42-2
- Formula:C43H62N8O5
- Molecular Weight:771.00
IUPAC Name: (S)-N-((S)-1-(((S)-1-(((S)-3-cyclopentyl-1-oxo-1-(((S)-1-(7-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)amino)propan-2-yl)amino)-3-(methylamino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-1-(4-methylpentanoyl)pyrrolidine-2-carboxamide
InChIKey: IUJXGKCRDZTFSX-BJPBVECGSA-N
SMILES: O=C([C@H]1N(CCC1)C(CCC(C)C)=O)N[C@@H](C(C)C)C(N[C@@H](CNC)C(N[C@@H](CC2CCCC2)C(N[C@H](C3=NC4=CC=CC(C5=CC=CC=C5)=C4N3)C)=O)=O)=O
Biological Activity: Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].
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Antitumor agent-69 | Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy. | |||||||||||||||||||||
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