2419160-96-4
Chemical Structure
DprE1-IN-4
- CAS No.: 2419160-96-4
- Formula:C20H21N3O5S
- Molecular Weight:415.46
IUPAC Name: methyl (2-(4-(piperidine-1-carbonyl)benzamido)thiophene-3-carbonyl)carbamate
InChIKey: HBXACXQRFJZTFF-UHFFFAOYSA-N
SMILES: O=C(OC)NC(C1=C(NC(C2=CC=C(C(N3CCCCC3)=O)C=C2)=O)SC=C1)=O
Biological Activity: DprE1-IN-4 is a potent and orally active noncovalent DprE1 inhibitor with an IC50 of 0.90 μg/mL. DprE1-IN-4 exhibits potent in vitro activity against M. tuberculosis H37Rv and drug-resistant tuberculosis strain with MIC values of 0.12 μg/mL and 0.24 μg/mL, respectively. DprE1-IN-4 displays acceptable pharmacokinetic property and shows significant bactericidal activity in an acute mouse model of tuberculosis.
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DprE1-IN-4 | DprE1-IN-4 is a potent and orally active noncovalent DprE1 inhibitor with an IC50 of 0.90 μg/mL. DprE1-IN-4 exhibits potent in vitro activity against M. tuberculosis H37Rv and drug-resistant tuberculosis strain with MIC values of 0.12 μg/mL and 0.24 μg/mL, respectively. DprE1-IN-4 displays acceptable pharmacokinetic property and shows significant bactericidal activity in an acute mouse model of tuberculosis. | |||||||||||||||||||||
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