2421122-61-2
2421122-61-2
Chemical Structure
HDAC-IN-45
- CAS No.: 2421122-61-2
- Formula:C25H20ClFN8O
- Molecular Weight:502.93
IUPAC Name: 4-((2-amino-6-((3-chloro-4-fluorophenyl)amino)-9H-purin-9-yl)methyl)-N-(2-aminophenyl)benzamide
InChIKey: BWFYYTOGYBJCQR-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1N)C2=CC=C(CN3C=NC4=C(NC5=CC=C(F)C(Cl)=C5)N=C(N)N=C34)C=C2
Biological Activity: HDAC-IN-45 (Compound 14) is a small molecule HDAC inhibitor and has anticancer activity, also can forms a hydrogen bond with residue Y303. HDAC-IN-45 (Compound 14) has substantial inhibitory effects towards HDAC1, 2 and 3 isoforms with IC50 values of 0.108, 0.585 and 0.563 μM respectively[1].
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HDAC-IN-45 | HDAC-IN-45 (Compound 14) is a small molecule HDAC inhibitor and has anticancer activity, also can forms a hydrogen bond with residue Y303. HDAC-IN-45 (Compound 14) has substantial inhibitory effects towards HDAC1, 2 and 3 isoforms with IC50 values of 0.108, 0.585 and 0.563 μM respectively. | |||||||||||||||||||||
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