2421127-99-1
2421127-99-1
Chemical Structure
hCAIX/XII-IN-5
- CAS No.: 2421127-99-1
- Formula:C18H13NO3
- Molecular Weight:291.30
IUPAC Name: (E)-3-(3-(phenylamino)acryloyl)-2H-chromen-2-one
InChIKey: LJJNSYXUPMRGNY-ZHACJKMWSA-N
SMILES: O=C1C(C(/C=C/NC2=CC=CC=C2)=O)=CC3=C(O1)C=CC=C3
Biological Activity: hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis[1].
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hCAIX/XII-IN-5 | hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis. | |||||||||||||||||||||
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