2426628-29-5
Chemical Structure
JH-XIV-68-3
- CAS No.: 2426628-29-5
- Formula:C22H19F3N8O
- Molecular Weight:468.43
IUPAC Name: (Z)-31,5-dimethyl-6-oxo-13-(trifluoromethyl)-11H,21H,31H-5-aza-2(3,5)-pyrrolo[2,3-b]pyridina-1(4,1),3(4,3)-dipyrazolacyclononaphane-35-carbonitrile
InChIKey: CZWJLLBPWLUINU-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=NN2C=C1C3=CNC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O
Biological Activity: JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].
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JH-XIV-68-3 | JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines. | |||||||||||||||||||||
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