24269-96-3
Chemical Structure
GRK2 Inhibitor 1
- CAS No.: 24269-96-3
- Formula:C12H9NO6
- Molecular Weight:263.20
IUPAC Name: methyl (E)-5-(2-(5-nitrofuran-2-yl)vinyl)furan-2-carboxylate
InChIKey: YDJPHSNZGRVPCK-NSCUHMNNSA-N
SMILES: O=C(OC)C1=CC=C(O1)/C=C/C2=CC=C(O2)[N+]([O-])=O
Biological Activity: GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time[1].
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GRK2 Inhibitor 1 | 98.06% | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time. | ||||||||||||||||||||
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