2428389-65-3
2428389-65-3
Chemical Structure
AChE-IN-20
- CAS No.: 2428389-65-3
- Formula:C22H20N8O6S2
- Molecular Weight:556.57
IUPAC Name: 4-((4,6-bis((4-sulfamoylphenyl)amino)-1,3,5-triazin-2-yl)amino)benzoic acid
InChIKey: RNJQUZMSEZRHNH-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC2=NC(NC3=CC=C(S(=O)(N)=O)C=C3)=NC(NC4=CC=C(S(=O)(N)=O)C=C4)=N2)C=C1)O
Biological Activity: AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively[1].
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AChE-IN-20 | AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively. | |||||||||||||||||||||
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References
- [1]. Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Chem. 2020 Jul;100:103897. [Content Brief]
