2428400-25-1
Chemical Structure
Thalidomide-NH-C10-Boc
- CAS No.: 2428400-25-1
- Formula:C28H39N3O6
- Molecular Weight:513.63
InChIKey: BKRGRRNJPWCAFN-UHFFFAOYSA-N
SMILES: O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(OC(C)(C)C)=O)=C3C1=O
Biological Activity: Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958)[1].
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Thalidomide-NH-C10-Boc | Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958). | |||||||||||||||||||||
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