2428478-22-0
2428478-22-0
Chemical Structure
NLRP3-IN-20
- CAS No.: 2428478-22-0
- Formula:C22H27N3O3S
- Molecular Weight:413.53
InChIKey: WHENNLLCPPZNFB-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(CN(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Biological Activity: NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].
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NLRP3-IN-20 | NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis. | |||||||||||||||||||||
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