2429877-78-9
Chemical Structure
PROTAC STAT3 degrader-2
- CAS No.: 2429877-78-9
- Formula:C59H60F2N9O13P
- Molecular Weight:1172.13
IUPAC Name: ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-(8-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oct-7-ynoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid
InChIKey: ZMCYXBJXBBCEIP-DYGUMZBISA-N
SMILES: O=C1C2=C(C#CCCCCCC(N3C[C@@H](C(N4[C@@](CC[C@H]4C(N[C@@H](CCC(N)=O)C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)=O)([H])CC3)=O)NC(C7=CC8=CC(C(F)(F)P(O)(O)=O)=CC=C8N7)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
Biological Activity: PROTAC STAT3 degrader-2 is a PROTAC degrader that targets STAT3, with a DC50 value of 3.54 μM. PROTAC STAT3 degrader-2 inhibits the growth of leukemia and lymphoma cells with high levels of phosphorylated STAT3. PROTAC STAT3 degrader-2 is used in the research of acute myeloid leukemia and anaplastic large cell lymphoma[1].
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PROTAC STAT3 degrader-2 | PROTAC STAT3 degrader-2 is a PROTAC degrader that targets STAT3, with a DC50 value of 3.54 μM. PROTAC STAT3 degrader-2 inhibits the growth of leukemia and lymphoma cells with high levels of phosphorylated STAT3. PROTAC STAT3 degrader-2 is used in the research of acute myeloid leukemia and anaplastic large cell lymphoma. | |||||||||||||||||||||
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