2429878-72-6
Chemical Structure
Lenalidomide-acetylene-C5-COOH
Synonym(s): Cereblon ligand-linker Conjugate
- CAS No.: 2429878-72-6
- Formula:C21H22N2O5
- Molecular Weight:382.41
IUPAC Name: 8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoic acid
InChIKey: UYYFKFKQSNARRT-UHFFFAOYSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)CC3=C1C=CC=C3C#CCCCCCC(O)=O
Biological Activity: Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC[1]. Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Lenalidomide-acetylene-C5-COOH | 99.26% | Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC. Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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