2433895-70-4
Chemical Structure
Ciapavir
Synonym(s): SBI-0953294
- CAS No.: 2433895-70-4
- Formula:C54H70N8O8S2
- Molecular Weight:1023.31
IUPAC Name: (4S,4'S,7S,7'S,9aS,9a'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]thiazepine-7-carboxamide)
InChIKey: QYUQEIDUJNTYDQ-FPKACUMUSA-N
SMILES: O=C([C@H]1N2[C@](SCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1(C)C)N[C@@H](C3=CC=CC=C3C4)[C@@H]4OCC#CC#CCO[C@@H]5CC6=CC=CC=C6[C@@H]5NC([C@H]7N8[C@](SCC[C@@H](C8=O)NC([C@H](C)NC)=O)([H])CC7(C)C)=O
Biological Activity: Ciapavir (SBI-0953294) is a HIV-1 latency-reversing agent. Ciapavir reverses latent HIV-1 reservoir in vitro and in vivo without inducing systemic T cell activation or broad cytokine release. Ciapavir degrades cIAP1 and activates non-canonical NF-κB pathway. Ciapavir can be used for the research of HIV-1 infection[1].
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Ciapavir | Ciapavir (SBI-0953294) is a HIV-1 latency-reversing agent. Ciapavir reverses latent HIV-1 reservoir in vitro and in vivo without inducing systemic T cell activation or broad cytokine release. Ciapavir degrades cIAP1 and activates non-canonical NF-κB pathway. Ciapavir can be used for the research of HIV-1 infection. | |||||||||||||||||||||
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