2434633-17-5
2434633-17-5
Chemical Structure
Aβ42-IN-1 free base
- CAS No.: 2434633-17-5
- Formula:C29H26N4O2
- Molecular Weight:462.54
IUPAC Name: 5-(8-([1,1'-biphenyl]-4-ylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl)-N-ethylpicolinamide
InChIKey: VNNXRQLFCKSSMH-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC
Biological Activity: Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 μM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease[1].
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Aβ42-IN-1 free base | Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 μM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease. | |||||||||||||||||||||
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