2439-04-5
2439-04-5
Chemical Structure
5-Hydroxyisoquinoline
- CAS No.: 2439-04-5
- Formula:C9H7NO
- Molecular Weight:145.16
IUPAC Name: isoquinolin-5-ol
InChIKey: CSNXUYRHPXGSJD-UHFFFAOYSA-N
SMILES: C1=CC=C(C2=CC=NC=C12)O
Biological Activity: 5-Hydroxyisoquinoline is a SARM1 inhibitor, IC50 = 2.6 μM, with axon-protective activity. 5-Hydroxyisoquinoline binds to and inhibits the NADase catalytic activity of the SARM1 protein TIR domain, reducing SARM1-mediated NAD+ depletion and cADPR production. 5-Hydroxyisoquinoline can be used in research on SARM1-related diseases; it can also serve as an intermediate for research related to organic synthesis[1][2][3][4][5].
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5-Hydroxyisoquinoline | 98.0% | 5-Hydroxyisoquinoline is a SARM1 inhibitor, IC50 = 2.6 μM, with axon-protective activity. 5-Hydroxyisoquinoline binds to and inhibits the NADase catalytic activity of the SARM1 protein TIR domain, reducing SARM1-mediated NAD+ depletion and cADPR production. 5-Hydroxyisoquinoline can be used in research on SARM1-related diseases; it can also serve as an intermediate for research related to organic synthesis. | ||||||||||||||||||||
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References
- [1]. Hughes RO, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell reports. 2021 Jan 05;34(1):108588. [Content Brief]
- [2]. Soukup O, et al. Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety. Bioorganic & medicinal chemistry. 2016 Feb 15;24(4):841-8. [Content Brief]
- [3]. IC Scopes D. Selective non-peptide kappa opioid receptor agonists. Expert Opinion on Investigational Drugs. 1994 Apr 1;3(4):369-77.
- [4]. Gunes CE, et al. Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar arene including multi quinoline units. Medicinal Chemistry Research. 2020 Jun;29(6):1077-83.
- [5]. He M, et al. Synthesis and Anti-Toxoplasma Activity In vitro of Arctigenin Derivatives. Letters in Drug Design & Discovery. 2024 Dec;21(19):4949-61. [Content Brief]
