2441860-09-7
2441860-09-7
Chemical Structure
NH2-C-Ph-hexyne-C4-NH2
- CAS No.: 2441860-09-7
- Formula:C13H18N2
- Molecular Weight:202.30
InChIKey: XBQFMUVKANQXDA-UHFFFAOYSA-N
SMILES: NCC1=CC=C(C#CCCCCN)C=C1
Biological Activity: NH2-C-Ph-hexyne-C4-NH2 is a PROTAC linker. NH2-C-Ph-hexyne-C4-NH2 can connect the BRD4 ligand JQ1 (HY-13030) with the SYVN1 ligand Clofibric acid (HY-B1415), thereby achieving the degradation of BRD4 via the PROTAC mechanism. NH2-C-Ph-hexyne-C4-NH2 can be used for the synthesis of PROTAC BRD4 Degrader-47 (HY-184455)[1].
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NH2-C-Ph-hexyne-C4-NH2 | NH2-C-Ph-hexyne-C4-NH2 is a PROTAC linker. NH2-C-Ph-hexyne-C4-NH2 can connect the BRD4 ligand JQ1 (HY-13030) with the SYVN1 ligand Clofibric acid (HY-B1415), thereby achieving the degradation of BRD4 via the PROTAC mechanism. NH2-C-Ph-hexyne-C4-NH2 can be used for the synthesis of PROTAC BRD4 Degrader-47 (HY-184455). | |||||||||||||||||||||
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