2444364-04-7
2444364-04-7
Chemical Structure
EGFR/HER2/TS-IN-2
- CAS No.: 2444364-04-7
- Formula:C26H21N7OS2
- Molecular Weight:511.62
IUPAC Name: 2-((5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenylpyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
InChIKey: BXTQVBISDVMYCS-UHFFFAOYSA-N
SMILES: N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5
Biological Activity: EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].
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EGFR/HER2/TS-IN-2 | EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM. | |||||||||||||||||||||
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