2444713-88-4
Chemical Structure
Carboxy pyridostatin trifluoroacetate salt
- CAS No.: 2444713-88-4
- Formula:C37H35F3N10O9
- Molecular Weight:820.73
IUPAC Name: 2,2,2-trifluoroacetic acid compound with 3-(4-(((2,6-bis((4-(2-aminoethoxy)quinolin-2-yl)carbamoyl)pyridin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid (1:1)
InChIKey: WTHDBHUUPVHFQX-UHFFFAOYSA-N
SMILES: O=C(O)CCN1N=NC(COC2=CC(C(NC3=NC4=CC=CC=C4C(OCCN)=C3)=O)=NC(C(NC5=NC6=CC=CC=C6C(OCCN)=C5)=O)=C2)=C1.FC(C(O)=O)(F)F
Biological Activity: Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carboxy pyridostatin trifluoroacetate salt | 99.49% | Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation. | ||||||||||||||||||||
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References
- [1]. Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518. [Content Brief]
- [2]. Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925. [Content Brief]
- [3]. Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441. [Content Brief]
