2445485-84-5
Chemical Structure
PYSNO
- CAS No.: 2445485-84-5
- Formula:C28H31N5O3S
- Molecular Weight:517.64
InChIKey: BLIYMRNWKHKTBJ-UHFFFAOYSA-N
SMILES: NC1=C(C=C(C=C1)C2=CC=C(S2)N3N=C(C=CC3=O)C4=CC=C(C=C4)OCCCCN5CCOCC5)N
Biological Activity: PYSNO is a lysosome-targeted fluorescent probe based on a pyridazinone skeleton (λem=515-565 nm, λex=405 nm) that can be used to track nitric oxide (NO) production in vivo. PYSNO exhibits a rapid, highly sensitive and highly selective "turn-on" response to endogenous and exogenous NO by blocking photoinduced electron transfer and regulating radiative decay rates. PYSNO enables precise in vivo monitoring in a mouse model of myocardial fibrosis and can be applied to the research of related diseases[1][2].
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PYSNO | PYSNO is a lysosome-targeted fluorescent probe based on a pyridazinone skeleton (λem=515-565 nm, λex=405 nm) that can be used to track nitric oxide (NO) production in vivo. PYSNO exhibits a rapid, highly sensitive and highly selective "turn-on" response to endogenous and exogenous NO by blocking photoinduced electron transfer and regulating radiative decay rates. PYSNO enables precise in vivo monitoring in a mouse model of myocardial fibrosis and can be applied to the research of related diseases. | |||||||||||||||||||||
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References
- [1]. Zhou T, et al. A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging. Anal Chem. 2020;92(7):5064-5072. [Content Brief]
- [2]. Dong X, et al. Theoretical insights into the linker effects on the turn-on fluorescence behaviors in pyridazinone-containing NO probes. Spectrochim Acta A Mol Biomol Spectrosc. 2024;321:124761. [Content Brief]
