244616-85-1
244616-85-1
Chemical Structure
Luotonin F
- CAS No.: 244616-85-1
- Formula:C18H11N3O2
- Molecular Weight:301.30
IUPAC Name: 2-(quinoline-3-carbonyl)quinazolin-4(3H)-one
InChIKey: HSEIGGKZBVNIDH-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41
Biological Activity: Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2].
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Luotonin F | Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II. | |||||||||||||||||||||
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References
- [1]. Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16(6):4861-83. [Content Brief]
- [2]. Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6. [Content Brief]
