2446474-05-9
Chemical Structure
Pomalidomide-C7-NH2 hydrochloride
Synonym(s): Pomalidomide 4'-alkylC7-amine hydrochloride
- CAS No.: 2446474-05-9
- Formula:C20H27ClN4O4
- Molecular Weight:422.91
IUPAC Name: 4-((7-aminoheptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
InChIKey: QICRZTGJMYJVAT-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCN)=O.[H]Cl
Biological Activity: Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC[1][2].
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Pomalidomide-C7-NH2 hydrochloride | 98.97% | Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC. | ||||||||||||||||||||
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Thalidomide-NH-C6-NH2 | Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | |||||||||||||||||||||
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Thalidomide-NH-C6-NH2 hydrochloride | 99.62% | Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||||||||||||||||||
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Thalidomide-NH-C5-NH2 | Thalidomide-NH-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | |||||||||||||||||||||
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Thalidomide-NH-C5-NH2 hydrochloride | 99.66% | Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||||||||||||||||||
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Thalidomide-NH-C8-NH2 | Thalidomide-NH-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | |||||||||||||||||||||
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Thalidomide-NH-C8-NH2 hydrochloride | Thalidomide-NH-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | |||||||||||||||||||||
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Pomalidomide-C11-NH2 hydrochloride | 96.84% | Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC. | ||||||||||||||||||||
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Pomalidomide-C7-NH2 | Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) (Compound 24g) is an E3 Ligase Ligand-Linker Conjugates consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-C7-NH2 can be used for synthesis of PROTACs. | |||||||||||||||||||||
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Thalidomide-NH-C9-NH2 hydrochloride | 99.88% | Thalidomide-NH-C9-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. | ||||||||||||||||||||
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Thalidomide-NH-C10-NH2 hydrochloride | 95.58% | Thalidomide-NH-C10-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. | ||||||||||||||||||||
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References
- [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]
- [2]. Si Woo Choi, et al. Hmg-coa reductase degradation inducing compound. Patent, WO2021201577A1.