2446965-04-2
2446965-04-2
Chemical Structure
JR5-26B
- CAS No.: 2446965-04-2
- Formula:C19H17FN6O
- Molecular Weight:364.38
SMILES: O=C(NC1=C2N=CC=CC2=CC(F)=C1)C3=NC=C(N=C3)N4C[C@@]5([C@H]([C@@]5(C4)[H])N)[H]
Biological Activity: JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively[1].
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JR5-26B | JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively. | |||||||||||||||||||||
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