2447066-14-8
Chemical Structure
BMS-1166-N-piperidine-CO-N-piperazine
- CAS No.: 2447066-14-8
- Formula:C41H43ClN4O5
- Molecular Weight:707.26
IUPAC Name: 3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-(piperazine-1-carbonyl)piperidin-1-yl)methyl)phenoxy)methyl)benzonitrile
InChIKey: IYPYUVUFRCLTFR-UHFFFAOYSA-N
SMILES: O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)N7CCNCC7
Biological Activity: BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
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BMS-1166-N-piperidine-CO-N-piperazine | BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. | |||||||||||||||||||||
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