2450341-39-4
2450341-39-4
Chemical Structure
DHODH-IN-21
- CAS No.: 2450341-39-4
- Formula:C20H19ClF4N6O4
- Molecular Weight:518.85
IUPAC Name: (S)-N-(2-chloro-4-methylpyridin-3-yl)-6-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)nicotinamide
InChIKey: XEDJGCIOZDHXOR-JTQLQIEISA-N
SMILES: O=C1N(C2=C(F)C=C(C(NC3=C(Cl)N=CC=C3C)=O)C(O[C@@H](C)C(F)(F)F)=N2)N=C(N1CC)CO
Biological Activity: DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1].
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DHODH-IN-21 | DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML). | |||||||||||||||||||||
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