245126-95-8
Chemical Structure
Phosphatidylinositol 4,5-bisphosphate
Synonym(s): L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2
- CAS No.: 245126-95-8
- Formula:C47H85O19P3
- Molecular Weight:1047.09
IUPAC Name: (2R)-1-((hydroxy(((1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl)oxy)phosphoryl)oxy)-3-(stearoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
InChIKey: CNWINRVXAYPOMW-FCNJXWMTSA-N
SMILES: O=P(O)(O)O[C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](OP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)(O)=O)[C@@H]1O)O)OP(O)(O)=O
Biological Activity: Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABAA receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema[1][2][3].
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Phosphatidylinositol 4,5-bisphosphate | Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABAA receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema. | |||||||||||||||||||||
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References
- [1]. Kooijman EE, et al. Phosphatidylinositol 4,5-bisphosphate stimulates alveolar epithelial fluid clearance in male and female adult rats. Am J Physiol Lung Cell Mol Physiol. 2011;301(5):L804-L811. [Content Brief]
- [2]. Arreola J, et al. Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate. Cell Calcium. 2019;84:102103. [Content Brief]
- [3]. Katan M, et al. Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane. Essays Biochem. 2020;64(3):513-531. [Content Brief]
