2451298-06-7
Chemical Structure
P-gp inhibitor 5
- CAS No.: 2451298-06-7
- Formula:C28H20ClNO5S
- Molecular Weight:517.98
IUPAC Name: 2-(2-chlorobenzamido)-6-(4-methoxyphenyl)-3-(thiophen-2-yl)benzofuran-4-yl acetate
InChIKey: NVHVRYUFNCFLGC-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C2=CC=CS2)C3=C(OC(C)=O)C=C(C4=CC=C(OC)C=C4)C=C3O1)C5=CC=CC=C5Cl
Biological Activity: P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 5 has antiproliferative activity against certain cancer cell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-InTM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015)[1].
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P-gp inhibitor 5 | P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 5 has antiproliferative activity against certain cancer cell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-InTM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015). | |||||||||||||||||||||
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