2451481-08-4
2451481-08-4
Chemical Structure
Sulfopin
Synonym(s): PIN1-3
- CAS No.: 2451481-08-4
- Formula:C11H20ClNO3S
- Molecular Weight:281.81
IUPAC Name: 2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide
InChIKey: NMHVAHHYKGXBMY-UHFFFAOYSA-N
SMILES: O=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl
Biological Activity: Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sulfopin | 99.82% | Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
