2455423-94-4
Chemical Structure
PCSK9-IN-15
- CAS No.: 2455423-94-4
- Formula:C22H28N6O2S2
- Molecular Weight:472.63
IUPAC Name: (S)-(4-hydroxypiperidin-1-yl)(2-((2-methyl-3-((5-(methylthio)pyrimidin-2-yl)amino)propyl)amino)benzo[d]thiazol-6-yl)methanone
InChIKey: MNEOZIJAHAESRI-AWEZNQCLSA-N
SMILES: O=C(N1CCC(CC1)O)C2=CC=C(N=C(S3)NC[C@@H](C)CNC4=NC=C(SC)C=N4)C3=C2
Biological Activity: PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia[1].
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PCSK9-IN-15 | PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia. | |||||||||||||||||||||
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