2458-08-4
2458-08-4
Chemical Structure
12-Ketochenodeoxycholic acid
- CAS No.: 2458-08-4
- Formula:C24H38O5
- Molecular Weight:406.56
IUPAC Name: ethyl 4-(4-bromophenoxy)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
InChIKey: MIHNUBCEFJLAGN-DMMBONCOSA-N
SMILES: C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O
Biological Activity: 12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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12-Ketochenodeoxycholic acid | 99.93% | 12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases. | ||||||||||||||||||||
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12-Ketochenodeoxycholic acid (Standard) | ≥98% | 12-Ketochenodeoxycholic acid (Standard) is an analytical standard of 12-Ketochenodeoxycholic acid (HY-W403933). This product is intended for research and analytical applications. 12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases. | ||||||||||||||||||||
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3β-Ursodeoxycholic acid (Standard) | ≥98% | 3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA. | ||||||||||||||||||||
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12-Ketodeoxycholic acid (Standard) | 99.91% | 12-Ketodeoxycholic acid (Standard) is the analytical standard of 12-Ketodeoxycholic acid. This product is intended for research and analytical applications. 12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury | ||||||||||||||||||||
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Ursodeoxycholic acid (Standard) | 99.83% | Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active. | ||||||||||||||||||||
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Ursodeoxycholic acid-13C | Ursodeoxycholic acid-13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active. | |||||||||||||||||||||
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Allochenodeoxycholic acid | Allochenodeoxycholic acid is a nucleoside metabolite. | |||||||||||||||||||||
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7,12-Diketolithocholic acid | 99.93% | 7,12-Diketolithocholic acid (7,12-Diketo-LCA) is a bile acid, which can be produced in the host-gut microbial co-metabolism of the bile acid pool. | ||||||||||||||||||||
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Chenodeoxycholic Acid (Standard) | 99.80% | Chenodeoxycholic Acid (Standard) is the analytical standard of Chenodeoxycholic Acid. This product is intended for research and analytical applications. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. | ||||||||||||||||||||
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Chenodeoxycholic acid-13C | 98.0% | Chenodeoxycholic acid-13C is the 13C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. | ||||||||||||||||||||
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Isochenodeoxycholic acid | 99.90% | Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction. | ||||||||||||||||||||
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3β-Cholic acid | 99.7% | 3β-Cholic acid is a derivative of cholic acid (HY-N0324), and can be found in human feces. | ||||||||||||||||||||
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References
- [1]. Sawada H, et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid[J]. European journal of applied microbiology and biotechnology, 1980, 10(1): 107-112.
- [2]. Kikuchi H. The metabolic sequence for the occurrence of an anomalous bile acid, 12-ketochenodeoxycholic acid, found in the bile of hepatobiliary diseased patients[J]. The Journal of Biochemistry, 1972, 72(1): 165-172.
