24587-49-3
24587-49-3
Chemical Structure
(E)-4-Hydroxycrotonic acid
Synonym(s): trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
- CAS No.: 24587-49-3
- Formula:C4H6O3
- Molecular Weight:102.09
IUPAC Name: (E)-4-hydroxybut-2-enoic acid
InChIKey: RMQJECWPWQIIPW-OWOJBTEDSA-N
SMILES: O=C(O)/C=C/CO
Biological Activity: (E)-4-Hydroxycrotonic acid (trans-4-Hydroxycrotonic acid) is a semirigid linear analog of γ-Hydroxybutyric acid. (E)-4-Hydroxycrotonic acid can be present in the mammalian central nervous system. (E)-4-Hydroxycrotonic acid binds to high-affinity γ-Hydroxybutyric acid binding sites and displaces radioligands[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E)-4-Hydroxycrotonic acid | 98.0% | (E)-4-Hydroxycrotonic acid (trans-4-Hydroxycrotonic acid) is a semirigid linear analog of γ-Hydroxybutyric acid. (E)-4-Hydroxycrotonic acid can be present in the mammalian central nervous system. (E)-4-Hydroxycrotonic acid binds to high-affinity γ-Hydroxybutyric acid binding sites and displaces radioligands. | ||||||||||||||||||||
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References
- [1]. Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. Journal of medicinal chemistry. 2017 Nov 09;60(21):9022-9039. [Content Brief]
- [2]. Schmitt M, et al. Synthesis of [3H]‐labelled trans 4‐hydroxycrotonic acid (T‐HCA), an endogenous substance interfering with 4‐hydroxybutyrate (GHB)[J]. Journal of Labelled Compounds and Radiopharmaceuticals, 1989, 27(1): 23-33.
