2459657-11-3
Chemical Structure
Antibacterial agent 106
- CAS No.: 2459657-11-3
- Formula:C20H24N6S
- Molecular Weight:380.51
IUPAC Name: (E)-2-(1-(2-(4-(4-(azetidin-1-yl)but-1-yn-1-yl)phenyl)-4-methylthiazol-5-yl)ethylidene)hydrazine-1-carboximidamide
InChIKey: RDVMZGPFIHEJNA-BUVRLJJBSA-N
SMILES: CC1=C(SC(C2=CC=C(C=C2)C#CCCN3CCC3)=N1)/C(C)=N/NC(N)=N
Biological Activity: Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages[1]. Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Antibacterial agent 106 | Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages. Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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