2460722-04-5
2460722-04-5
Chemical Structure
Oveporexton
Synonym(s): TAK-861
- CAS No.: 2460722-04-5
- Formula:C23H25F5N2O4S
- Molecular Weight:520.51
InChIKey: KVMGAIOTUIGROS-AZUAARDMSA-N
SMILES: CC(C)(O)C(N(CC(F)([C@@H]1NS(CC)(=O)=O)F)[C@H]1CC2=C(C(C3=CC(F)=CC(F)=C3)=CC=C2)F)=O
Biological Activity: Oveporexton (TAK-861) is an orally active and selective orexin receptor 2 (OX2R) agonist with an EC50 of 2.5 nM. Oveporexton exhibits 3000-fold selectivity for OX2R over OX1R. Oveporexton can be used for the study of hypersomnia disorders including narcolepsy[1][2].
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Oveporexton | 99.68% | Oveporexton (TAK-861) is an orally active and selective orexin receptor 2 (OX2R) agonist with an EC50 of 2.5 nM. Oveporexton exhibits 3000-fold selectivity for OX2R over OX1R. Oveporexton can be used for the study of hypersomnia disorders including narcolepsy. | ||||||||||||||||||||
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References
- [1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 38, No. 2, 2024.
- [2]. Mitsukawa K, et al. TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models. Sci Rep. 2024 Sep 6;14(1):20838. [Content Brief]
