2463197-87-5
2463197-87-5
Chemical Structure
EGFR-IN-152
- CAS No.: 2463197-87-5
- Formula:C29H35N9O2S
- Molecular Weight:573.71
InChIKey: RNEHWYIFHKBZAW-DEOSSOPVSA-N
SMILES: CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N([C@@H]5CN(CC5)S(=O)(C6CC6)=O)C(NC7=CC=CC=C7)=N4)=N3
Biological Activity: EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
EGFR-IN-152 | EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
