2470908-79-1
Chemical Structure
YS-370
- CAS No.: 2470908-79-1
- Formula:C37H35BrN4O3
- Molecular Weight:663.60
IUPAC Name: 4-(3-((4-(1-(2-bromobenzyl)-2-phenyl-1H-indol-3-yl)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
InChIKey: WSOJDUFWINGDJI-UHFFFAOYSA-N
SMILES: COC1=CC2=NC=NC(C3=C(C4=CC=CC=C4)N(CC5=CC=CC=C5Br)C6=C3C=CC=C6)=C2C=C1OCCCN7CCOCC7
Biological Activity: YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1].
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YS-370 | 98.07% | YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. | ||||||||||||||||||||
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