2472802-77-8
2472802-77-8
Chemical Structure
Emupertinib
Synonym(s): TAS3351
- CAS No.: 2472802-77-8
- Formula:C30H26N8O
- Molecular Weight:514.58
InChIKey: NKRUHCMBVJSNAB-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C)N=C1)NC23CCC(CC2)(C3)N4C(C#C)=C(C5=C4N=CN=C5N)C6=CC7=C(C=CC=C7)N=C6
Biological Activity: Emupertinib (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Emupertinib | 99.10% | Emupertinib (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively. | ||||||||||||||||||||
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