2482992-54-9
2482992-54-9
Chemical Structure
HDAC-IN-36
- CAS No.: 2482992-54-9
- Formula:C29H39N5O5
- Molecular Weight:537.65
IUPAC Name: 6-(4-(5,7-dimethoxy-4-(4-methylpiperazin-1-yl)quinazolin-2-yl)-2,6-dimethylphenoxy)-N-hydroxyhexanamide
InChIKey: NTUCJWZWDDQYER-UHFFFAOYSA-N
SMILES: COC1=CC(OC)=C2C(N=C(N=C2N3CCN(CC3)C)C4=CC(C)=C(C(C)=C4)OCCCCCC(NO)=O)=C1
Biological Activity: HDAC-IN-36 (compound 23 g) is an orally active and potent HDAC (histone deacetylase) inhibitor, with an IC50 of 11.68 nM (HDAC6). HDAC-IN-36 promotes apoptosis, autophagy and suppresses migration. HDAC-IN-36 shows anti-tumor and anti-metastatic activity, and can be used for breast cancer research[1].
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HDAC-IN-36 | HDAC-IN-36 (compound 23 g) is an orally active and potent HDAC (histone deacetylase) inhibitor, with an IC50 of 11.68 nM (HDAC6). HDAC-IN-36 promotes apoptosis, autophagy and suppresses migration. HDAC-IN-36 shows anti-tumor and anti-metastatic activity, and can be used for breast cancer research. | |||||||||||||||||||||
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