2482998-34-3
Chemical Structure
HDAC1-IN-16
- CAS No.: 2482998-34-3
- Formula:C22H23N7O2
- Molecular Weight:417.47
IUPAC Name: 2-(2-((6-cyano-1-methyl-1H-indol-3-yl)methyl)-2,6-diazaspiro[3.4]octan-6-yl)-N-hydroxypyrimidine-5-carboxamide
InChIKey: WBVFFDSDELAGSY-UHFFFAOYSA-N
SMILES: N#CC=1C=CC2=C(C1)N(C=C2CN3CC4(CN(C5=NC=C(C=N5)C(=O)NO)CC4)C3)C
Biological Activity: HDAC1-IN-16 is a potent and selective HDAC1 inhibitor and antimalarial agent, with IC50 values of 2.2 nM and 0.223-0.248 nM against hHDAC1 and PfHDAC1, respectively. HDAC1-IN-16 induces histone hyperacetylation by inhibiting PfHDAC1, interferes with gene expression, thereby inhibits merozoite growth and reinvasion, and exhibits killing effects in the erythrocytic, hepatic, and gametocyte stages. HDAC1-IN-16 can be used for research on malaria[1].
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HDAC1-IN-16 | HDAC1-IN-16 is a potent and selective HDAC1 inhibitor and antimalarial agent, with IC50 values of 2.2 nM and 0.223-0.248 nM against hHDAC1 and PfHDAC1, respectively. HDAC1-IN-16 induces histone hyperacetylation by inhibiting PfHDAC1, interferes with gene expression, thereby inhibits merozoite growth and reinvasion, and exhibits killing effects in the erythrocytic, hepatic, and gametocyte stages. HDAC1-IN-16 can be used for research on malaria. | |||||||||||||||||||||
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