2484255-85-6
2484255-85-6
Chemical Structure
HDAC8/BRPF1-IN-1
- CAS No.: 2484255-85-6
- Formula:C19H19N3O6S
- Molecular Weight:417.44
IUPAC Name: 3-(N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)sulfamoyl)-N-hydroxy-4-methoxybenzamide
InChIKey: HVHLFMDXTXHXRM-UHFFFAOYSA-N
SMILES: O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1
Biological Activity: HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1].
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HDAC8/BRPF1-IN-1 | HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6. | |||||||||||||||||||||
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