2484683-99-8
Chemical Structure
HPsensor 2
- CAS No.: 2484683-99-8
- Formula:C22H27BF2N4O3
- Molecular Weight:444.28
InChIKey: YDJAERLZFIQIFJ-UHFFFAOYSA-N
SMILES: F[B-]1([N+]2=C(NCCOC)C=CC2=C(C3=CC=C(N31)NCCOC)C4=CC=C(C=C4)OC)F
Biological Activity: HPsensor 2 is a fluorescent probe used to detect the surface hydrophobicity of proteins. The detection mechanism of HPsensor 2 relies on its amphipathic properties. The 2-methoxyethylamine substituents at positions 3 and 5 of its BODIPY core enhance water solubility, enabling it to interact with solvent-exposed hydrophobic regions on proteins. When it binds to these hydrophobic surfaces, the free rotation of the meso-aryl substituent is restricted, increasing molecular rigidity and reducing non-radiative deactivation, which results in a significant enhancement of fluorescence. HPsensor 2 exhibits weak but detectable fluorescence in aqueous environments, and its fluorescence is highly sensitive to changes in protein surface hydrophobicity (Ex/Em = 528/579 nm)[1].
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HPsensor 2 | HPsensor 2 is a fluorescent probe used to detect the surface hydrophobicity of proteins. The detection mechanism of HPsensor 2 relies on its amphipathic properties. The 2-methoxyethylamine substituents at positions 3 and 5 of its BODIPY core enhance water solubility, enabling it to interact with solvent-exposed hydrophobic regions on proteins. When it binds to these hydrophobic surfaces, the free rotation of the meso-aryl substituent is restricted, increasing molecular rigidity and reducing non-radiative deactivation, which results in a significant enhancement of fluorescence. HPsensor 2 exhibits weak but detectable fluorescence in aqueous environments, and its fluorescence is highly sensitive to changes in protein surface hydrophobicity (Ex/Em = 528/579 nm). | |||||||||||||||||||||
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