2484771-19-7
2484771-19-7
Chemical Structure
HF50731
- CAS No.: 2484771-19-7
- Formula:C26H46N4
- Molecular Weight:414.67
IUPAC Name: N1,N1'-(1,4-phenylenebis(methylene))bis(N3-cyclohexylpropane-1,3-diamine)
InChIKey: HAKFGEFAVSVPJO-UHFFFAOYSA-N
SMILES: C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1
Biological Activity: HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HF50731 | 99.66% | HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM. | ||||||||||||||||||||
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References
- [1]. Fang X, Meng Q, Zhang H, Liang B, Zhu S, Wang J, Zhang C, Huang LS, Zhang X, Schooley RT, An J, Xu Y, Huang Z. Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists. Eur J Med Chem. 2020 Aug 15;200:112410. [Content Brief]
