2484862-54-4
Chemical Structure
Sec61-IN-3
- CAS No.: 2484862-54-4
- Formula:C25H26N4O2S
- Molecular Weight:446.56
IUPAC Name: N-(4-(2-(1-phenylethoxy)propan-2-yl)thiazol-2-yl)-1-(pyridin-4-ylmethyl)-1H-pyrrole-2-carboxamide
InChIKey: WYXUQEFSQHVHIW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN1CC2=CC=NC=C2)NC3=NC(C(OC(C4=CC=CC=C4)C)(C)C)=CS3
Biological Activity: Sec61-IN-3 is a Sec61 inhibitor. Sec61-IN-3 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), and also has certain inhibitory activity on Her3 (IC50 = 99 nM), IL2 (IC50 = 144 nM) related reporter pathways, but has a relatively weak inhibitory effect on the TNFα (IC50 = 580 nM) pathway. Sec61-IN-3 can be used for cancer research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sec61-IN-3 | 99.33% | Sec61-IN-3 is a Sec61 inhibitor. Sec61-IN-3 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), and also has certain inhibitory activity on Her3 (IC50 = 99 nM), IL2 (IC50 = 144 nM) related reporter pathways, but has a relatively weak inhibitory effect on the TNFα (IC50 = 580 nM) pathway. Sec61-IN-3 can be used for cancer research. | ||||||||||||||||||||
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