2489250-48-6
Chemical Structure
TXX-1-10
- CAS No.: 2489250-48-6
- Formula:C23H18Cl3IN4O
- Molecular Weight:599.68
InChIKey: WEKZNMIDMWMCQC-UHFFFAOYSA-N
SMILES: CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NC4=CC=C[N+](C)=C4)=O.[I-]
Biological Activity: TXX-1-10 is a HPIP inhibitor. TXX-1-10 reduces HPIP expression and disrupts the formation of the EGFR-RAS-ERK signaling complex. TXX-1-10 inhibits AKT and ERK1/2 phosphorylation/activation and inhibits FAK and paxillin phosphorylation. TXX-1-10 induces G1 cell cycle arrest and apoptosis, and inhibits cancer cell proliferation, migration, invasion, epithelial-mesenchymal transition, and tumor growth/metastasis. TXX-1-10 can be used for research on breast cancer and lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TXX-1-10 | TXX-1-10 is a HPIP inhibitor. TXX-1-10 reduces HPIP expression and disrupts the formation of the EGFR-RAS-ERK signaling complex. TXX-1-10 inhibits AKT and ERK1/2 phosphorylation/activation and inhibits FAK and paxillin phosphorylation. TXX-1-10 induces G1 cell cycle arrest and apoptosis, and inhibits cancer cell proliferation, migration, invasion, epithelial-mesenchymal transition, and tumor growth/metastasis. TXX-1-10 can be used for research on breast cancer and lung cancer. | |||||||||||||||||||||
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References
- [1]. Li P, et al. A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein. Cell death discovery. 2021 Jul 29;7(1):198.
- [2]. Jiang Q, et al. HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis. Science advances. 2023 Jun 09;9(23):eade1155.
