2489430-53-5
Chemical Structure
Izicopan
Synonym(s): INF056
- CAS No.: 2489430-53-5
- Formula:C33H31F8N3O2
- Molecular Weight:653.61
IUPAC Name: (2R,3S,5R)-2-(4-(cyclopentylamino)phenyl)-1-(2,6-difluorobenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)-5-(trifluoromethyl)piperidine-3-carboxamide
InChIKey: BPWYUCDDEBSUBZ-WMQVBLFHSA-N
SMILES: O=C(C1=C(C=CC=C1F)F)N2[C@@H](C3=CC=C(C=C3)NC4CCCC4)[C@H](C[C@H](C2)C(F)(F)F)C(NC5=CC(C(F)(F)F)=C(C=C5)C)=O
Biological Activity: Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses[1].
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Izicopan | Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses. | |||||||||||||||||||||
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