2492376-85-7
2492376-85-7
Chemical Structure
PI3K/mTOR Inhibitor-8
- CAS No.: 2492376-85-7
- Formula:C23H22N8O4S
- Molecular Weight:506.54
IUPAC Name: 2-(2-aminopyrimidin-5-yl)-N'-(4-methoxybenzoyl)-4-morpholinothieno[3,2-d]pyrimidine-6-carbohydrazide
InChIKey: AIGSGJXYLHDMBA-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=NC(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=C2S1)NNC(C5=CC=C(OC)C=C5)=O
Biological Activity: PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].
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PI3K/mTOR Inhibitor-8 | PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase. | |||||||||||||||||||||
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